CXCR3 modulates obesity-induced visceral adipose inflammation and systemic insulin resistance
نویسندگان
چکیده
منابع مشابه
Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance
Obesity-induced chronic systemic inflammation has been considered as a major risk factor for the development of type 2 diabetes mellitus (T2DM). In addition, the development of inflammation in adipose tissue has been speculated to be the main resource to initialize systemic inflammation and insulin resistance in the state of obesity. However, the molecular mechanisms underlying the development ...
متن کاملObesity-Induced Inflammation and Insulin Resistance
Immune response and metabolic regulation are highly integrated and this interface maintains a central homeostatic system, dysfunction of which can cause obesity-associated metabolic disorder such as type 2 diabetes, fatty liver disease, and cardiovascular disease. Insulin resistance is an underlying basis for the pathogenesis of these metabolic diseases. Overnutrition or obesity activates the i...
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A major component of obesity-related insulin resistance is the establishment of a chronic inflammatory state with invasion of white adipose tissue by mononuclear cells. This results in the release of pro-inflammatory cytokines, which in turn leads to insulin resistance in target tissues such as skeletal muscle and liver. To determine the role of insulin action in macrophages and monocytes in ob...
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Obesity constitutes a critical risk factor for the development of many life threatening diseases, particularly insulin resistance and type 2 diabetes. Adipose tissue plays an important role in regulating whole body energy homeostatsis and obesity-related insulin resistance. Inflammation has been commonly linked to insulin resistance. Recent studies demonstrated that adipose tissue is an importa...
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The early events that initiate inflammation in the adipose tissue during obesity are not well defined. It is unclear whether the recruitment of CD8 T cells to the adipose tissue during onset of obesity occurs through antigen-dependent or -independent processes. We have previously shown that interaction between NKG2D (natural-killer group 2, member D) and its ligand Rae-1ε is sufficient to recru...
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ژورنال
عنوان ژورنال: Obesity
سال: 2014
ISSN: 1930-7381
DOI: 10.1002/oby.20642